Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown