Add to ORKGBax is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the regulation of apoptosis. Bax can be activated by various stimuli and translocate to the mitochondria, where it induces cytochrome c release and caspase activation. Bax expression or activity can be altered in colon cancer cells, resulting in resistance to apoptosis and tumor progression. This article summarized the molecular mech-anisms of Bax activation and function in apoptosis, the alterations of Bax expression or activity in colon cancer cells, and the potential thera-peutic implications of targeting Bax or its regulators in colon cancer
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Apoptotic desensitization is a hallmark of cancer cells, but present knowledge of molecular systems ...
Loss of apoptotic Bax due to microsatellite mutation contributes to tumor development and chemoresis...
Loss of apoptotic Bax due to microsatellite mutation contributes to tumor development and chemoresis...
AbstractThe rate of tumour growth is dependent on the balance between proliferation and apoptosis at...
The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all apopt...
Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Beca...
Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pat...
Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pat...
629-637Apoptosis is genetically programmed mechanism of cellular death, triggered by various physiol...
We have recently shown that the transcriptional coactivator PGC1α, a master regulator of mitochondri...
We have recently shown that the transcriptional coactivator PGC1α, a master regulator of mitochondri...
Background: NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet,...
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax and B...
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Apoptotic desensitization is a hallmark of cancer cells, but present knowledge of molecular systems ...
Loss of apoptotic Bax due to microsatellite mutation contributes to tumor development and chemoresis...
Loss of apoptotic Bax due to microsatellite mutation contributes to tumor development and chemoresis...
AbstractThe rate of tumour growth is dependent on the balance between proliferation and apoptosis at...
The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all apopt...
Programmed cell death (apoptosis) plays a vital role in the regulation of cellular homeostasis. Beca...
Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pat...
Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pat...
629-637Apoptosis is genetically programmed mechanism of cellular death, triggered by various physiol...
We have recently shown that the transcriptional coactivator PGC1α, a master regulator of mitochondri...
We have recently shown that the transcriptional coactivator PGC1α, a master regulator of mitochondri...
Background: NSAIDs exhibit protective properties towards some cancers, especially colon cancer. Yet,...
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax and B...
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Cancer is the second leading cause of death in the United States. Thus, understanding the mechanisms...
Apoptotic desensitization is a hallmark of cancer cells, but present knowledge of molecular systems ...