Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed whether the physicochemical properties of these assemblies vary as a function of the constituent oligonucleotide (ODN) sequence and/or composition. The present study was aimed at answering this question. To this end, we complexed N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTAP) liposomes, in dispersion, with either 18-mer phosphorothiote homo-oligonucleotides composed of either adenine, thymidine or cytosine; or one of three structurally related 18-mer phosphorothioate oligonucleotides (S-ODNs) (G3139, its reverse sequence and its two-base mismatch). After ODN addition to vesicles at different mole ratios, changes in pH an...
Abstract31P-NMR and UV spectroscopies were used to study the interactions between cationic amphiphil...
In this work, we investigate the effect of a small single-stranded oligonucleotide (ODN) on the coll...
AbstractFormation of liposome/polynucleotide complexes (lipoplexes) involves electrostatic interacti...
Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed wh...
Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed wh...
AbstractLipoplexes, which are spontaneously formed complexes between oligonucleotide (ODN) and catio...
The association behavior of different nucleic acids with cationic liposomes has been monitored, in o...
Lipoplexes with different surface charge were prepared from a short oligonucleotide (20 mer, dsAT) i...
Complexes between short oligodeoxynucleotides (ODN) with a variable dGxdCy base composition and lipo...
AbstractpH-sensitive liposomes made of dioleoylphosphatidylethanolamine (DOPE)/oleic acid (OA)/chole...
AbstractLipoplexes, which are complexes between cationic liposomes (L+) and nucleic acids, are commo...
Liposomes are considered very promising delivery systems for antisense therapeutic approach, offerin...
AbstractCationic lipid-nucleic acid complexes (lipoplexes) consisting of dioleoyltrimethylammoniumpr...
Lipoplexes constituted by calf-thymus DNA (CT-DNA) and mixed cationic liposomes consisting of varyin...
AbstractSeveral studies have demonstrated that lipoplexes are two-phase systems over most mixing lip...
Abstract31P-NMR and UV spectroscopies were used to study the interactions between cationic amphiphil...
In this work, we investigate the effect of a small single-stranded oligonucleotide (ODN) on the coll...
AbstractFormation of liposome/polynucleotide complexes (lipoplexes) involves electrostatic interacti...
Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed wh...
Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed wh...
AbstractLipoplexes, which are spontaneously formed complexes between oligonucleotide (ODN) and catio...
The association behavior of different nucleic acids with cationic liposomes has been monitored, in o...
Lipoplexes with different surface charge were prepared from a short oligonucleotide (20 mer, dsAT) i...
Complexes between short oligodeoxynucleotides (ODN) with a variable dGxdCy base composition and lipo...
AbstractpH-sensitive liposomes made of dioleoylphosphatidylethanolamine (DOPE)/oleic acid (OA)/chole...
AbstractLipoplexes, which are complexes between cationic liposomes (L+) and nucleic acids, are commo...
Liposomes are considered very promising delivery systems for antisense therapeutic approach, offerin...
AbstractCationic lipid-nucleic acid complexes (lipoplexes) consisting of dioleoyltrimethylammoniumpr...
Lipoplexes constituted by calf-thymus DNA (CT-DNA) and mixed cationic liposomes consisting of varyin...
AbstractSeveral studies have demonstrated that lipoplexes are two-phase systems over most mixing lip...
Abstract31P-NMR and UV spectroscopies were used to study the interactions between cationic amphiphil...
In this work, we investigate the effect of a small single-stranded oligonucleotide (ODN) on the coll...
AbstractFormation of liposome/polynucleotide complexes (lipoplexes) involves electrostatic interacti...