Regional variation in p2 receptor expression in the rat pulmonary arterial circulation
- Chootip, K.
- Ness, K.F.
- Wang, Y.
- Gurney, A.M.
- Kennedy, C.
DOIAbstract
The P2 receptors that mediate contraction of the rat isolated small (SPA, 200–500 μm i.d.) and large (LPA, 1–1.5 mm i.d.) intrapulmonary arteries were characterized. In endothelium-denuded vessels the contractile order of potency was α,β-methyleneATP (α,β-meATP)>>UDP=UTP=ATP=2-methylthioATP>ADP in the SPA and α,β-meATP=UTPUDP>2-methylthioATP, ATP>>ADP in the LPA. α,β-meATP, 2-methylthioATP and ATP had significantly greater effects in the SPA than the LPA (P<0.001), but there was no difference in the potency of UTP or UDP between the vessels. In the SPA, P2X1 receptor desensitisation by α,β-meATP (100 μm) inhibited contractions to α,β-meATP (10 nm–300 μm), but not those to UTP or UDP (100 nm–300 μm). In the LPA, prolonged exposure to α,β-meA...
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