Gastric Adenocarinoma of Fundic Gland Type - Spectrum of Morphological and Immunohistochemical Patterns

Background and objective:  Fundic gland adenocarcinoma of stomach is a distinct entity. This study investigated the clinico-pathological features, diagnosis and differential diagnosis of gastric adenocarcinoma of fundic gland type (GA-FG). Methods:  A total of 16 cases of GA-FG were collected, their clinical characteristics were analyzed, histopathological and immunophenotypic characteristics were observed, and the relevant literature was reviewed. Results:  There was no typical clinical manifestation of GA-FG. 16 patients were basically hospitalized with abdominal discomfort. Histopathology of GA-FG showed the diffuse multilayering and nuclear stratification with mild cytologic atypia and minimal stromal reaction even in invasive front. Conclusion: Adenocarcinoma of gastric fundus is a novel histologic type of gastric cancer. Its diagnosis is mainly based on the patho-morphological characteristics with supporting immunohistochemistry. The prognosis is good, and it needs long-term follow-up.