Gut_microbiome_in_ESLD_and_Lung_Transplantation_STORMS_Excel.xlsx

We assessed the gut microbiome in 64 faecal samples from end-stage lung disease patients before transplantation and 219 samples from lung transplant recipients after transplantation using metagenomic sequencing. To identify dysbiotic microbial signatures, we analysed 243 faecal samples from age-, sex- and BMI-matched healthy controls. By unsupervised clustering, we identified five groups of lung transplant recipients using different combinations of immunosuppressants and antibiotics and analysed them in relation to the gut microbiome. Finally, we investigated the gut microbiome composition of lung transplant recipients in different chronic lung allograft dysfunction stages and longitudinal gut microbiome changes after transplantation.