The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infections with antibiotics. The tripartite efflux pump AcrAB-NodT confers adaptive MDR in the polarized α-proteobacterium Caulobacter crescentus via transcriptional induction by first-generation quinolone antibiotics. We discovered that overexpression of AcrAB-NodT by mutation or exogenous inducers confers resistance to cephalosporin and penicillin (β-lactam) antibiotics. Combining 2-step mutagenesis-sequencing (Mut-Seq) and cephalosporin-resistant point mutants, we dissected how TipR uses a common operator of the divergent tipR and acrAB-nodT promoter for adaptive and/or potentiated AcrAB-NodT-directed efflux. Chemical screening identified divers...
The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medic...
Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria a...
Multiple Antibiotic Resistance Regulators (MarRs) are DNA binding proteins involved in bacterial sur...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to und...
(A) Schematic of the tipR/acrAB-nodT locus and the repression of the divergent promoter by TipR, whi...
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic...
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to und...
ABSTRACT Antibiotic resistance has become a major public health concern as bacteria evolve to evade ...
Drug efflux by resistance-nodulation-cell division (RND)-type transporters, such as AcrAB-ToIC of Es...
BackgroundThe Resistance-Nodulation-Division (RND) family transporter AcrB plays a major role in the...
Gram‐negative bacteria are intrinsically resistant against cytotoxic substances by means of their ou...
The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medic...
Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria a...
Multiple Antibiotic Resistance Regulators (MarRs) are DNA binding proteins involved in bacterial sur...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The acquisition of multidrug resistance (MDR) determinants jeopardizes treatment of bacterial infect...
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to und...
(A) Schematic of the tipR/acrAB-nodT locus and the repression of the divergent promoter by TipR, whi...
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to antibiotic...
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to und...
ABSTRACT Antibiotic resistance has become a major public health concern as bacteria evolve to evade ...
Drug efflux by resistance-nodulation-cell division (RND)-type transporters, such as AcrAB-ToIC of Es...
BackgroundThe Resistance-Nodulation-Division (RND) family transporter AcrB plays a major role in the...
Gram‐negative bacteria are intrinsically resistant against cytotoxic substances by means of their ou...
The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medic...
Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria a...
Multiple Antibiotic Resistance Regulators (MarRs) are DNA binding proteins involved in bacterial sur...