Memory CD4⁺ T cells repopulated faster than naïve CD4⁺ T cells in blood following termination of antibody treatment.

The frequency of naïve (A, CD27+CD45RA+), central memory (B, CD27+CD45RA-), and effector memory (C, CD27-CD45RA-) CD4+ T cells in the peripheral blood was longitudinally determined by flow cytometry. Blue arrows in A show the timing of 4 anti-CD4 antibody administrations to the anti-CD4 antibody treatment group. Anti-CD4 antibody treated animals (n = 6) are shown in red; control animals (n = 4) are shown in black. Data are expressed as mean ± SEM. Statistical analyses were performed using unpaired two-sided Mann–Whitney U-tests. Statistical significance was considered when P (TIF)