Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised. We sought to define the detailed cellular pathology of astrocytes, the extent of population variation and the relationship to Alzheimer-type changes in a population-based cohort. Three staining patterns were associated with GFAP and excitatory amino acid transporter 2 (EAAT2): minimal, moderate or extensive immunoreactivity. GFAP and EAAT2 expression were inversely related (p=0.015), with trends to increased expression of GFAP (p=0.019) and decreased expression of EAAT2 (p=ns) with increasing Braak stage. GFAP and EAAT2 correlated incompletely with β-amyloid and tau immunoreactivity. However, gliosis increased with incre...
Alzheimer’s disease (AD) is the most common form of dementia in our society. The disease is characte...
Alzheimer’s disease (AD) is the leading cause of dementia among elderly in the United States. There ...
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Y...
Background: the cellular pathology of astrocytes in brain ageing and their role in modulating the br...
Background: The cellular pathology of astrocytes in brain ageing and their role in modulating the br...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
Alzheimer’s disease causes between 60% and 70% of all cases of dementia. Astrocytes maintain water, ...
We show in this thesis that different subtypes of astrocytes comprise specialized GFAP-IF networks, ...
Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse formati...
Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzhei...
Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzhei...
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle decline in...
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle decline in...
Alzheimer\u27s disease (AD) is a neurodegenerative disease that is characterized by two classical pa...
The role of astrocytes in neurodegenerative diseases has been previously overlooked. Over the past d...
Alzheimer’s disease (AD) is the most common form of dementia in our society. The disease is characte...
Alzheimer’s disease (AD) is the leading cause of dementia among elderly in the United States. There ...
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Y...
Background: the cellular pathology of astrocytes in brain ageing and their role in modulating the br...
Background: The cellular pathology of astrocytes in brain ageing and their role in modulating the br...
Classical immunohistochemical studies in the Alzheimer disease (AD) brain reveal prominent glial rea...
Alzheimer’s disease causes between 60% and 70% of all cases of dementia. Astrocytes maintain water, ...
We show in this thesis that different subtypes of astrocytes comprise specialized GFAP-IF networks, ...
Astrocytes contribute to a variety of functions in the brain, including homeostasis, synapse formati...
Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzhei...
Reactive astrocytes were identified as a component of senile amyloid plaques in the cortex of Alzhei...
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle decline in...
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle decline in...
Alzheimer\u27s disease (AD) is a neurodegenerative disease that is characterized by two classical pa...
The role of astrocytes in neurodegenerative diseases has been previously overlooked. Over the past d...
Alzheimer’s disease (AD) is the most common form of dementia in our society. The disease is characte...
Alzheimer’s disease (AD) is the leading cause of dementia among elderly in the United States. There ...
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Y...