Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.
- Wechsler, ME
- Scelo, G
- Larenas-Linnemann, DES
- Torres-Duque, CA
- Maspero, J
- Tran, TN
- Murray, RB
- Martin, N
- Menzies-Gow, AN
- Hew, M
- Peters, MJ
- Gibson, PG
- Christoff, GC
- Popov, TA
- Côté, A
- Bergeron, C
- Dorscheid, D
- FitzGerald, JM
- Chapman, KR
- Boulet, LP
- Bhutani, M
- Sadatsafavi, M
- Jiménez-Maldonado, L
- Duran-Silva, M
- Rodriguez, B
- Celis-Preciado, CA
- Cano-Rosales, DJ
- Solarte, I
- Fernandez-Sanchez, MJ
- Parada-Tovar, P
- von Bülow, A
- Bjerrum, AS
- Ulrik, CS
- Assing, KD
- Rasmussen, LM
- Hansen, S
- Altraja, A
- Bourdin, A
- Taille, C
- Charriot, J
- Roche, N
- Papaioannou, AI
- Kostikas, K
- Papadopoulos, NG
- Salvi, S
- Long, D
- Mitchell, PD
- Costello, R
- Sirena, C
- Cardini, C
- Heffler, E
- Puggioni, F
- Canonica, GW
- Guida, G
- Iwanaga, T
- Al-Ahmad, M
- García, U
- Kuna, P
- Fonseca, JA
- Al-Lehebi, R
- Koh, MS
- Rhee, CK
- Cosio, BG
- Perez de Llano, L
- Perng, D-W
- Huang, EW-C
- Wang, H-C
- Tsai, M-J
- Mahboub, B
- Salameh, LIJ
- Jackson, DJ
- Busby, J
- Heaney, LG
- Pfeffer, PE
- Goddard, AG
- Wang, E
- Hoyte, FCL
- Chapman, NM
- Katial, R
- Carter, V
- Bulathsinhala, L
- Eleangovan, N
- Ariti, C
- Lyu, J
- Porsbjerg, C
- Price, DB
DOIAbstract
RATIONALE: Previous studies investigating comorbidity impact on biologic effectiveness have been relatively small, of short duration, and have not compared biologic classes. OBJECTIVES: To determine the association between T2-related comorbidities and biologic effectiveness in adults with severe asthma (SA). METHODS: This cohort study used International Severe Asthma Registry data (n=21 countries, 2017-2022) to quantify pre- to post-biologic change for four outcomes (annual asthma exacerbation rate, % predicted FEV1 (ppFEV1), asthma control, and long-term oral corticosteroid daily dose [LTOCS]) in patients with/without allergic rhinitis (AR), chronic rhinosinusitis +/- nasal polyps (CRS+/-NP), NP, or eczema/atopic dermatitis (AD). MAIN RESU...
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