A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.
- Granell, R
- Curtin, JA
- Haider, S
- Kitaba, NT
- Mathie, SA
- Gregory, LG
- Yates, LL
- Tutino, M
- Hankinson, J
- Perretti, M
- Vonk, JM
- Arshad, HS
- Cullinan, P
- Fontanella, S
- Roberts, GC
- Koppelman, GH
- Simpson, A
- Turner, SW
- Murray, CS
- Lloyd, CM
- Holloway, JW
- Custovic, A
- UNICORN and Breathing Together investigators
DOIAbstract
BACKGROUND: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes. METHODS: We conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9568 individuals from five UK birth cohorts. RESULTS: Forty-four independent SNPs were associated with early-onset persistent, 25 with pre-school remitting, 33 with mid-childhood remitting, and 32 with late-onset wheeze. ...
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