This research demonstrates the potential role of Raman spectroscopy, combined with principle components analysis (PCA), as a diagnostic method. Analyses of ethically approved ex vivo post-mortem brain tissues (originating from frontal and occipital lobes) from control (3 normal elderly subjects and 3 Huntingdon's disease subjects) and Alzheimer's disease (12 subjects) brain sections, and a further set of 12 blinded samples are presented. Spectra originating from these tissues are highly reproducible, and initial results indicate a vital difference in protein content and conformation, relating to the abnormally high levels of aggregated proteins in the diseased tissues. Further examination of these spectra using PCA allows for the separation...
Accurate identification of Alzheimer’s disease (AD) is still of major clinical importance considerin...
Neuritic plaques and neurofibrillary tangles are crucial morphological criteria for the definite dia...
[EN] The present invention relates to a Raman spectroscopy method for determining protein structure ...
This research demonstrates the potential role of Raman spectroscopy, combined with principle compone...
The continuous increasing rate of patients suffering of Alzheimer’s disease (AD) worldwide requires ...
Alzheimer disease (AD) is the most frequent dementia. The prevalence is approximately 10% in 65 year...
Alzheimer’s disease (AD) is the most common form of dementia, which is one of the main death leading...
The continuous increasing rate of patients suffering of Alzheimer's disease (AD) worldwide requires ...
The pathogenesis underlining many neurodegenerative diseases remains incompletely understood. The la...
Alzheimer's disease (AD) is the most common form of dementia, which is one of the main death leading...
SIGNIFICANCE: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was ...
The growing burden of neurodegenerative diseases on society necessitates the development of improved...
Significance: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was ...
Raman spectroscopy was used to examine unstained, formalin fixed Alzheimer's disease human brain tis...
The Raman phenomenon is based on the spontaneous inelastic scattering of light, which depends on the...
Accurate identification of Alzheimer’s disease (AD) is still of major clinical importance considerin...
Neuritic plaques and neurofibrillary tangles are crucial morphological criteria for the definite dia...
[EN] The present invention relates to a Raman spectroscopy method for determining protein structure ...
This research demonstrates the potential role of Raman spectroscopy, combined with principle compone...
The continuous increasing rate of patients suffering of Alzheimer’s disease (AD) worldwide requires ...
Alzheimer disease (AD) is the most frequent dementia. The prevalence is approximately 10% in 65 year...
Alzheimer’s disease (AD) is the most common form of dementia, which is one of the main death leading...
The continuous increasing rate of patients suffering of Alzheimer's disease (AD) worldwide requires ...
The pathogenesis underlining many neurodegenerative diseases remains incompletely understood. The la...
Alzheimer's disease (AD) is the most common form of dementia, which is one of the main death leading...
SIGNIFICANCE: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was ...
The growing burden of neurodegenerative diseases on society necessitates the development of improved...
Significance: A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was ...
Raman spectroscopy was used to examine unstained, formalin fixed Alzheimer's disease human brain tis...
The Raman phenomenon is based on the spontaneous inelastic scattering of light, which depends on the...
Accurate identification of Alzheimer’s disease (AD) is still of major clinical importance considerin...
Neuritic plaques and neurofibrillary tangles are crucial morphological criteria for the definite dia...
[EN] The present invention relates to a Raman spectroscopy method for determining protein structure ...