Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile IP3Rs, yet Ca2+ puffs occur at a few immobile IP3R clusters. By imaging cells with endogenous IP3Rs tagged with EGFP, we show that KRas-induced actin-interacting protein (KRAP) tethers IP3Rs to actin beneath the plasma membrane. Loss of KRAP abolishes Ca2+ puffs and the global increases in cytosolic Ca2+ concentration evoked by more intense stimulation. Over-expressing KRAP immobilizes additional IP3R clusters and results in more Ca2+ puffs and larger global Ca2+ signals. Endogenous KRAP determines which IP3Rs will respond...
IP3 receptors (IP3Rs) are key players involved in the release of the crucial second messenger Ca2+ i...
Summary: Voltage-gated calcium channels (Cavs) are major Ca2+ entry pathways in excitable cells. The...
AbstractRecent results indicate that ‘regulators of G-protein signalling’ may contribute to the gene...
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest b...
Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the ...
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest b...
Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, ...
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surf...
The versatility of Ca2+ signals derives from their spatio-temporal organization1,2. For Ca2+ signals...
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization...
All three subtypes of inositol 1,4,5-trisphosphate receptor (IP3R) are intracellular Ca2+ channels t...
AbstractBackground: Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic t...
Summary: Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistr...
The building blocks for intracellular Ca2+ signals evoked by inositol 1,4,5-trisphosphate receptors ...
The inositol trisphosphate (IP3) signaling pathway evokes local Ca2+ signals (Ca2+ puffs) that arise...
IP3 receptors (IP3Rs) are key players involved in the release of the crucial second messenger Ca2+ i...
Summary: Voltage-gated calcium channels (Cavs) are major Ca2+ entry pathways in excitable cells. The...
AbstractRecent results indicate that ‘regulators of G-protein signalling’ may contribute to the gene...
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest b...
Abstract: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the ...
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest b...
Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, ...
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surf...
The versatility of Ca2+ signals derives from their spatio-temporal organization1,2. For Ca2+ signals...
IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization...
All three subtypes of inositol 1,4,5-trisphosphate receptor (IP3R) are intracellular Ca2+ channels t...
AbstractBackground: Ca2+ waves allow effective delivery of intracellular Ca2+ signals to cytosolic t...
Summary: Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistr...
The building blocks for intracellular Ca2+ signals evoked by inositol 1,4,5-trisphosphate receptors ...
The inositol trisphosphate (IP3) signaling pathway evokes local Ca2+ signals (Ca2+ puffs) that arise...
IP3 receptors (IP3Rs) are key players involved in the release of the crucial second messenger Ca2+ i...
Summary: Voltage-gated calcium channels (Cavs) are major Ca2+ entry pathways in excitable cells. The...
AbstractRecent results indicate that ‘regulators of G-protein signalling’ may contribute to the gene...