Modelling interactions between host and gut microbiota.

International audienceIntestinal host-microbiota interactions form a symbiosis mainly regulated atthe intestinal crypt level. These crosstalks play a major role in ensuring the health of thehost. Modelling these interactions is a further step to understand the behaviour of thisecosystem and determine whether healthy states can be recovered after a deteriorationof the host-microbiota symbiosis. Using a crypt model structured in space and celltypes proposed in [1], we added new components such as inflammatory response atthe epithelial cells scale, mucus production and degradation as well as the presence ofdifferent bacterial families (strict or facultative anaerobic, mucus degrader, pathobiont)inspired from [2]. We investigate if this model is able to simulate switches from healthyhost-microbiota interactions to chronic inflammation.1] L. Darrigade et al. A pdmp model of the epithelial cell turn-over in the intestinalcrypt including microbiota-derived regulations. HAL, 2021.[2] R. Muñoz-Tamayo et al. Mathematical modelling of carbohydrate degradation byhuman colonic microbiota. Journal of theoretical biology, 2010