The Fragile X Syndrome (FXS), the most common inherited intellectualdisability, is caused by a loss-of-function mutation in the FMR1 gene encoding the Fragile X Messenger Ribonucleoprotein (FMRP). The morphological hallmark of FXS in humans and Fmr1 knockout (KO) mice is an abnormally high density and immature morphology of dendritic spines on cortical pyramidal neurons (PyrNs). To determine whether this phenotype arises cell-autonomously from the lack of FMRP, we sparsely deleted FMRP from layer 5 PyrNs and imaged these cells in vivo in adolescence and adulthood. We found that single-cell Fmr1 KO in adulthood does not affect spine density, morphology, or dynamics, but neonatal Fmr1 KO leads to normal spine density yet elevated spine format...
Fragile X syndrome (FXS) is characterized by intellectual disability and autistic traits, and result...
International audienceFragile X is the most common cause of inherited intellectual disability and a ...
Fragile X Syndrome (FXS) and the Fmr1 knockout (KO) mouse model of this disorder exhibit abnormal de...
Fragile X syndrome (FXS) is the most common form of intellectual disability that arises from the dys...
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by silencing...
BackgroundFragile X syndrome (FXS) is the most common type of mental retardation attributable to a s...
In patients with Fragile X syndrome the fmr1 gene is silenced, leading to a lack of expression of th...
Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and autism. The d...
International audienceIntroduction: Fragile X syndrome (FXS), resulting from a mutation in the Fmr1 ...
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and results fr...
Fragile X syndrome is caused by a mutation in the FMR1 gene leading to absence of the fragile X ment...
Despite advances in understanding the pathophysiology of Fragile X syndrome (FXS), its molecular bas...
Fragile X syndrome (FXS) is the most common form of genetically inherited mental retardation and alt...
Fragile-X syndrome (FXS) is the most common form of inherited intellectual disability (ID), represen...
AbstractFragile X Syndrome (FXS) is the most common form of inherited intellectual disability, cause...
Fragile X syndrome (FXS) is characterized by intellectual disability and autistic traits, and result...
International audienceFragile X is the most common cause of inherited intellectual disability and a ...
Fragile X Syndrome (FXS) and the Fmr1 knockout (KO) mouse model of this disorder exhibit abnormal de...
Fragile X syndrome (FXS) is the most common form of intellectual disability that arises from the dys...
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by silencing...
BackgroundFragile X syndrome (FXS) is the most common type of mental retardation attributable to a s...
In patients with Fragile X syndrome the fmr1 gene is silenced, leading to a lack of expression of th...
Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and autism. The d...
International audienceIntroduction: Fragile X syndrome (FXS), resulting from a mutation in the Fmr1 ...
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and results fr...
Fragile X syndrome is caused by a mutation in the FMR1 gene leading to absence of the fragile X ment...
Despite advances in understanding the pathophysiology of Fragile X syndrome (FXS), its molecular bas...
Fragile X syndrome (FXS) is the most common form of genetically inherited mental retardation and alt...
Fragile-X syndrome (FXS) is the most common form of inherited intellectual disability (ID), represen...
AbstractFragile X Syndrome (FXS) is the most common form of inherited intellectual disability, cause...
Fragile X syndrome (FXS) is characterized by intellectual disability and autistic traits, and result...
International audienceFragile X is the most common cause of inherited intellectual disability and a ...
Fragile X Syndrome (FXS) and the Fmr1 knockout (KO) mouse model of this disorder exhibit abnormal de...