Add to ORKGThe human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres. We implemented a nanopore sequencing strategy to generate high-quality reads that span hundreds of kilobases of highly repetitive DNA in a human Y chromosome centromere. Combining these data with short-read variant validation, we assembled and characterized the centromeric region of a human Y chromosome
We report the sequencing and assembly of a reference genome for the human GM12878 Utah/Ceph cell lin...
Mapping studies of the centromeric region of the human Y chromosome Construction of a map of a human...
Chromosome inheritance depends on centromeres, epigenetically specified regions of chromosomes. Whil...
The human genome reference sequence remains incomplete owing to the challenge of assembling long tra...
The centromere is an important region of the chromosome which ensures correct segregation at cell di...
Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly di...
We have localized the DNA sequences required for mitotic centromere function on the human Y chromoso...
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near ...
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near ...
We are entering into an exciting era of genomics where truly complete, high-quality assemblies of hu...
Centromeres serve a critical function in preserving genome integrity across sequential cell division...
The centromere is the chromosomal locus essential for chromosome inheritance and genome stability. H...
Existing human genome assemblies have almost entirely excluded highly repetitive sequences within an...
Recent advances in long-read sequencing technologies allowed generation of the first complete assemb...
Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-s...
We report the sequencing and assembly of a reference genome for the human GM12878 Utah/Ceph cell lin...
Mapping studies of the centromeric region of the human Y chromosome Construction of a map of a human...
Chromosome inheritance depends on centromeres, epigenetically specified regions of chromosomes. Whil...
The human genome reference sequence remains incomplete owing to the challenge of assembling long tra...
The centromere is an important region of the chromosome which ensures correct segregation at cell di...
Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly di...
We have localized the DNA sequences required for mitotic centromere function on the human Y chromoso...
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near ...
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near ...
We are entering into an exciting era of genomics where truly complete, high-quality assemblies of hu...
Centromeres serve a critical function in preserving genome integrity across sequential cell division...
The centromere is the chromosomal locus essential for chromosome inheritance and genome stability. H...
Existing human genome assemblies have almost entirely excluded highly repetitive sequences within an...
Recent advances in long-read sequencing technologies allowed generation of the first complete assemb...
Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-s...
We report the sequencing and assembly of a reference genome for the human GM12878 Utah/Ceph cell lin...
Mapping studies of the centromeric region of the human Y chromosome Construction of a map of a human...
Chromosome inheritance depends on centromeres, epigenetically specified regions of chromosomes. Whil...