Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectiveness of cancer treatments. The reciprocal communication between CSCs and the tumor microenvironment (TME) is observed, with the TME providing a supportive niche for CSC survival and self-renewal, while CSCs, in turn, influence the polarization and persistence of the TME, promoting an immunosuppressive state. Consequently, these interactions hinder the efficacy of current cancer therapies, necessitating the exploration of novel therapeutic approaches to modulate the TME and target CSCs. In this review, we highlight the intricate strategie...
Tumor heterogeneity represents an important limitation to the development of effective cancer therap...
Cancer therapy is experiencing a paradigm shift due to the clinical success of immune checkpoint inh...
Mounting evidence from the literature suggests the existence of a subpopulation of cancer stem cells...
Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that i...
Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes. Howe...
Despite the recent advances in cancer patient management and in the development of targeted therapie...
Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiat...
Cancer stem cells (CSCs) have provided new insights into the tumorigenesis and metastatic potential ...
Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized i...
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have success...
Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized i...
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CS...
Despite gains in knowledge of the intrinsic signals governing cancer progression, effective clinical...
Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiat...
Tumors pose a significant threat to human health. Although many methods, such as operations, chemoth...
Tumor heterogeneity represents an important limitation to the development of effective cancer therap...
Cancer therapy is experiencing a paradigm shift due to the clinical success of immune checkpoint inh...
Mounting evidence from the literature suggests the existence of a subpopulation of cancer stem cells...
Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that i...
Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes. Howe...
Despite the recent advances in cancer patient management and in the development of targeted therapie...
Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiat...
Cancer stem cells (CSCs) have provided new insights into the tumorigenesis and metastatic potential ...
Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized i...
Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have success...
Tumor cells able to recapitulate tumor heterogeneity have been tracked, isolated and characterized i...
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CS...
Despite gains in knowledge of the intrinsic signals governing cancer progression, effective clinical...
Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiat...
Tumors pose a significant threat to human health. Although many methods, such as operations, chemoth...
Tumor heterogeneity represents an important limitation to the development of effective cancer therap...
Cancer therapy is experiencing a paradigm shift due to the clinical success of immune checkpoint inh...
Mounting evidence from the literature suggests the existence of a subpopulation of cancer stem cells...