Early-onset Alzheimers disease (AD) is highly heritable, yet only 10% of cases are associated with known pathogenic mutations. For early-onset AD patients without an identified autosomal dominant cause, we hypothesized that their early-onset disease reflects further enrichment of the common risk-conferring single nucleotide polymorphisms associated with late-onset AD. We applied a previously validated polygenic hazard score for late-onset AD to 193 consecutive patients diagnosed at our tertiary dementia referral center with symptomatic early-onset AD. For comparison, we included 179 participants with late-onset AD and 70 healthy controls. Polygenic hazard scores were similar in early- versus late-onset AD. The polygenic hazard score was not...
Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically un...
Sporadic early onset Alzheimer’s disease (sEOAD) exhibits the symptoms of late onset Alzheimer’s dis...
Understanding genetic influences on Alzheimer's disease (AD) may improve early identification. AD po...
ObjectiveTo examine associations between aggregate genetic risk and Alzheimer disease (AD) markers i...
Objective: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers...
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most commo...
BackgroundIdentifying individuals at risk for developing Alzheimer disease (AD) is of utmost importa...
Stratification by genetic risk factors for Alzheimer's disease (AD) may help identify groups with th...
Sporadic early-onset Alzheimer's disease (sEOAD) exhibits the symptoms of late-onset Alzheimer's dis...
Progress in clinical and basic research of Alzheimer's disease (AD) suggested theoretical models of ...
Sporadic early onset Alzheimer’s disease (sEOAD) exhibits the symptoms of late onset Alzheimer’s dis...
The identification of subjects at high risk for Alzheimer's disease is important for prognosis and e...
• Because of growing evidence for genetic causes of Alzheimer disease, clinicians are often asked ab...
Alzheimer's disease (AD) is a neurodegenerative disorder that preferentially affects individuals of ...
Objective: Genome‐wide association studies (GWAS) have identified over 30 susceptibility loci assoc...
Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically un...
Sporadic early onset Alzheimer’s disease (sEOAD) exhibits the symptoms of late onset Alzheimer’s dis...
Understanding genetic influences on Alzheimer's disease (AD) may improve early identification. AD po...
ObjectiveTo examine associations between aggregate genetic risk and Alzheimer disease (AD) markers i...
Objective: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers...
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most commo...
BackgroundIdentifying individuals at risk for developing Alzheimer disease (AD) is of utmost importa...
Stratification by genetic risk factors for Alzheimer's disease (AD) may help identify groups with th...
Sporadic early-onset Alzheimer's disease (sEOAD) exhibits the symptoms of late-onset Alzheimer's dis...
Progress in clinical and basic research of Alzheimer's disease (AD) suggested theoretical models of ...
Sporadic early onset Alzheimer’s disease (sEOAD) exhibits the symptoms of late onset Alzheimer’s dis...
The identification of subjects at high risk for Alzheimer's disease is important for prognosis and e...
• Because of growing evidence for genetic causes of Alzheimer disease, clinicians are often asked ab...
Alzheimer's disease (AD) is a neurodegenerative disorder that preferentially affects individuals of ...
Objective: Genome‐wide association studies (GWAS) have identified over 30 susceptibility loci assoc...
Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically un...
Sporadic early onset Alzheimer’s disease (sEOAD) exhibits the symptoms of late onset Alzheimer’s dis...
Understanding genetic influences on Alzheimer's disease (AD) may improve early identification. AD po...