Add to ORKGThis study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfused rat liver (IPRL) studies have been reported not to be consistent with the well stirred model of organ elimination when only entering and exiting liver concentration measurements are available. First, the time dependency of diazepam equilibrium fraction unbound measurements from 4 to 24 hours was tested, reporting the continuing increases with time. The results showed that the time dependency of equilibrium protein-binding measurements for very highly bound drugs may be an issue that is not readily overcome. When examining C out/C in (F obs) measurements for diazepam when no protein is added to the incubation media, IPRL outcomes were consis...
For almost a half-century clearance concepts have been utilized in pharmacokinetics to understand th...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfuse...
This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfuse...
To discriminate between two widely used models of hepatic drug elimination, the venous equilibrium a...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
Hepatic drug clearance of xenobiotics comprises a complex interplay between sinusoidal uptake, intra...
Clearance, or a measure of the body’s ability to remove drug, is a crucial pharmacokinetic parameter...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
For almost a half-century clearance concepts have been utilized in pharmacokinetics to understand th...
For almost a half-century clearance concepts have been utilized in pharmacokinetics to understand th...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfuse...
This study re-examined the hepatic extraction for diazepam, the only drug for which isolated perfuse...
To discriminate between two widely used models of hepatic drug elimination, the venous equilibrium a...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
In reviewing previously published isolated perfused rat liver studies, we find no experimental data ...
Hepatic drug clearance of xenobiotics comprises a complex interplay between sinusoidal uptake, intra...
Clearance, or a measure of the body’s ability to remove drug, is a crucial pharmacokinetic parameter...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
A number of experimental observations in the late 1960s, early 1970s could not be explained by the p...
For almost a half-century clearance concepts have been utilized in pharmacokinetics to understand th...
For almost a half-century clearance concepts have been utilized in pharmacokinetics to understand th...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...
The liver is a major site for synthesis and catabolism of plasma proteins. Albumin has various bindi...