Adjuvant treatment of malignant melanoma

Zaradi naraščajoče incidence malignega melanoma potekajo številne raziskave o pomenu dodatnega zdravljenja po odstranitvi primarnega tumorja, ker je zdravljenje napredovale bolezni žal še vedno neučinkovito. Največ raziskav v zadnjih letih je na področju uporabe interferona-alfa. Rezultati nekaterih raziskav skupin bolnikov z visokim tveganjem so ohrabrujoči. Čeprav poteka veliko randomiziranih multicentričih raziskav standardni odmerek in optimalna shema zdravljenja še nista ugotovljeni. Predstavljeni so tudi nekateri novi pristopi, predvsem na področju tumorskih vakcin.Considering rapidly increasing incidence and the high mortallity rates observed in advanced melanoma numerous studies of adjuvant treatment are investigating the possible benefit of various approaches. During the past years some progress has been made in treatment of cutaneous melanoma. Recent studies mostly involve the use of interferon-alfa. Promising results have beenreported in high risk patients with high dose IFN-alfa, though a standard regimen has been established yet. The results of ongoing studies are presentedand discussed and some new possible approaches with vaccines are mentioned