Biological and Neuroimaging Markers as Predictors of 5-Year Incident Frailty in Older Adults: A Secondary Analysis of the MAPT Study
- Lu, Wan-Hsuan
- de Souto Barreto, Philipe
- Rolland, Yves
- Bouyahia, Ali
- Fischer, Clara
- Mangin, Jean-François
- Giudici, Kelly
- Vellas, Bruno
- Guyonnet, Sophie
- Carrié, Isabelle
- Brigitte, Lauréane
- Faisant, Catherine
- Lala, Françoise
- Delrieu, Julien
- Villars, Hélène
- Combrouze, Emeline
- Badufle, Carole
- Analysis, Statistical
- Andrieu, Sandrine
- Cantet, Christelle
- Morin, Christophe
- Abellan van Kan, Gabor
- Dupuy, Charlotte
- Rolland, Yves
- Caillaud, Céline
- Ousset, Pierre-Jean
- Lala, Françoise
- Willis, Sherry
- Belleville, Sylvie
- Gilbert, Brigitte
- Fontaine, Francine
- Dartigues, Jean-François
- Marcet, Isabelle
- Delva, Fleur
- Foubert, Alexandra
- Cerda, Sandrine
- Costes, Corinne
- Rouaud, Olivier
- Manckoundia, Patrick
- Quipourt, Valérie
- Marilier, Sophie
- Franon, Evelyne
- Bories, Lawrence
- Pader, Marie-Laure
- Basset, Marie-France
- Lapoujade, Bruno
- Faure, Valérie
- Li Yung Tong, Michael
- Malick-Loiseau, Christine
- Cazaban-Campistron, Evelyne
- Desclaux, Françoise
- Blatge, Colette
- Dantoine, Thierry
- Laubarie-Mouret, Cécile
- Saulnier, Isabelle
- Clément, Jean-Pierre
- Picat, Marie-Agnès
- Bernard-Bourzeix, Laurence
- Willebois, Stéphanie
- Désormais, Iléana
- Cardinaud, Noëlle
- Bonnefoy, Marc
- Livet, Pierre
- Rebaudet, Pascale
- Gédéon, Claire
- Burdet, Catherine
- Pesce, Alain
- Roth, Stéphanie
- Chaillou, Sylvie
- Louchart, Sandrine
- Sudres, Kristel
- Lebrun, Nicolas
- Barro-Belaygues, Nadège
- Touchon, Jacques
- Bennys, Karim
- Gabelle, Audrey
- Romano, Aurélia
- Touati, Lynda
- Marelli, Cécilia
- Pays, Cécile
- Robert, Philippe
- Le Duff, Franck
- Gervais, Claire
- Gonfrier, Sébastien
- Gasnier, Yannick
- Begorre, Danièle
- Carpuat, Christian
- Khales, Khaled
- Lefebvre, Jean-François
- Misbah El Idrissi, Samira
- Skolil, Pierre
- Salles, Jean-Pierre
- Dufouil, Carole
- Lehéricy, Stéphane
- Chupin, Marie
- Mangin, Jean-François
- Bouhayia, Ali
- Allard, Michèle
- Ricolfi, Frédéric
- Dubois, Dominique
- Paule Bonceour Martel, Marie
- Cotton, François
- Bonafé, Alain
- Chanalet, Stéphane
- Hugon, Françoise
- Bonneville, Fabrice
- Cognard, Christophe
- Chollet, François
- Payoux, Pierre
- Voisin, Thierry
- Delrieu, Julien
- Peiffer, Sophie
- Hitzel, Anne
- Allard, Michèle
- Zanca, Michel
- Monteil, Jacques
- Darcourt, Jacques
- Molinier, Laurent
- Derumeaux, Hélène
- Costa, Nadège
- Perret, Bertrand
- Vinel, Claire
- Caspar-Bauguil, Sylvie
- Olivier-Abbal, Pascale
- Andrieu, Sandrine
- Cantet, Christelle
- Coley, Nicola
DOIAbstract
International audienceBackground This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers ...
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