To study the demographic profile of HCC patients and the pattern of clinical characteristics in a tertiary care centre of north western India

Hepatocellular carcinoma (HCC) is a prevalent malignancy globally and the fifth most common cancer worldwide. This retrospective study, spanning six years, explores the shifting etiological patterns of HCC in Northwestern India, particularly influenced by factors like Hepatitis B and C endemics, alcohol consumption, and vaccination programs. Data from 164 HCC patients reveal a significant shift, with Hepatitis C surpassing Hepatitis B as the primary etiological factor. The study highlights the distinctive HCC profile in Northwestern India, emphasizing the imperative to address HCV as a silent precursor to HCC and the need for enhanced surveillance and intervention strategies. The findings underscore the significance of controlling alcohol abuse, managing cirrhosis complications, and the urgency for improved diagnostic markers beyond AFP. The study prompts a reevaluation of vaccination interventions and advocates for heightened screening measures to detect and mitigate HCV-related HCC at earlier stages