Direct effects of methotrexate on osteoblasts 1) Methotrexate Suppresses Inflammatory Agonist Induced Interleukin 6 Synthesis in Osteoblasts 2) Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts

A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis

Le Goff, Benoit
Soltner, Elise
Charrier, Céline
Maugars, Yves
Rédini, Françoise
Heymann, Dominique
Berthelot, Jean-Marie

January 2009

International audienceIntroductionOsteoclasts play a key role in the pathogenesis of bone erosion an...

Mechanism of Action of Methotrexate: Experimental Evidence that Methotrexate Blocks the Binding of Interleukin 1 β to the Interleukin 1 Receptor on Target Cells

Marlene Brody
Ingrid B Hm
R. Bauer

January 1993

Summary: Interleukin 1, a multifunctional cytokine, plays a central role in inflammatory processes a...

Prevention of methotrexate chemotherapy-induced bone growth arrest and osteoporosis with folinic acid.

Fan, Chiaming

January 2011

During childhood and adolescence, bone continues to lengthen through endochondral ossification, whic...

Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects

Xian, C.
Cool, J.
Scherer, M.
Pyragius, C.
Fan, C.
Covino, M.
Foster, B.

January 2007

Methotrexate chemotherapy promotes osteoclast formation in the long bone of rats via increased pro-inflammatory cytokines and enhanced NF-kappa B activation

King, T.
Georgiou, K.
Cool, J.
Scherer, M.
Ang, E.
Foster, B.
Xu, J.
Xian, C.

January 2012

Cancer chemotherapy with methotrexate (MTX) is known to cause bone loss. However, the underlying mec...

Effects of methotrexate on human bone cell respones to mechanical stimulation.

Elliot, K. J
Millward-Sadler, S. J
Wright, M. O
Robb, J E
Wallace, W. H. B
Salter, D M

October 2004

Objectives. Methotrexate (MTX), which is prescribed in the treatment of malignancy and autoimmune di...

The role of osteocyte apoptosis in cancer chemotherapy-induced bone loss

Shandala, T.
Ng, Y.
Hopwood, B.
Yip, Y.
Foster, B.
Xian, C.

January 2012

Intensive cancer chemotherapy leads to significant bone loss, the underlying mechanism of which rema...

Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow

Georgiou, K.
Scherer, M.
Fan, C.
Cool, J.
King, T.
Foster, B.
Xian, C.

January 2012

Intensive use of cancer chemotherapy is increasingly linked with long-term skeletal side effects suc...

Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis

Ji Yeon Sung
Jang Hee Hong
Hyung Sik Kang
In Pyo Choi
Sang Deok Lim
June Kyu Lee
Jeong Ho Seok
Jae Heun Lee
Gang Min Hur

January 2000

Various cytokines and reactive oxygen species (ROS) play a fundamental role in the inflammatory and ...

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

Annussek Tobias
Kleinheinz Johannes
Thomas Szuwart
Joos Ulrich
Wermker Kai

September 2012

Abstract Introduction Due to increasing use of disease modifying antirheumatic drugs (DMARDs) as fir...

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast´s proliferation in vitro

Annussek, T. (Tobias)
Kleinheinz, J. (Johannes)
Szuwart, T. (Thomas)
Joos, U. (Ulrich)
Wermker, K. (Kai)

March 2013

Introduction: Due to increasing use of disease modifying antirheumatic drugs (DMARDs) as first line ...

The short- and long-term effects of methotrexate on the rat skeleton

Wheeler, D L
Vander Griend, R A
Wronski, T J
Miller, G J
Keith, E E
Graves, James, PhD

February 1995

Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has ...

Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis.

Gerards, A.H.
Lathouder, S de
Groot, E.R.
Dijkmans, B.A.C.
Aarden, L.A.

January 2003

OBJECTIVES: To analyse whether the beneficial effects of methotrexate in rheumatoid arthritis (RA) c...

Effects of Resveratrol Supplementation on Methotrexate Chemotherapy‐Induced Bone Loss

Alice Lee

March 2017

Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...

Effects of resveratrol supplementation on methotrexate chemotherapy-induced bone loss

Lee, Alice M. C.
Shandala, Tetyana
Soo, Pei Pei
Su, Yu-Wen
King, Tristan J.
Chen, Ke-Ming
Howe, Peter R.
Xian, Cory J.

January 2017

Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...

A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis

Le Goff, Benoit
Soltner, Elise
Charrier, Céline
Maugars, Yves
Rédini, Françoise
Heymann, Dominique
Berthelot, Jean-Marie

January 2009

International audienceIntroductionOsteoclasts play a key role in the pathogenesis of bone erosion an...

Mechanism of Action of Methotrexate: Experimental Evidence that Methotrexate Blocks the Binding of Interleukin 1 β to the Interleukin 1 Receptor on Target Cells

Marlene Brody
Ingrid B Hm
R. Bauer

January 1993

Summary: Interleukin 1, a multifunctional cytokine, plays a central role in inflammatory processes a...

Prevention of methotrexate chemotherapy-induced bone growth arrest and osteoporosis with folinic acid.

Fan, Chiaming

January 2011

During childhood and adolescence, bone continues to lengthen through endochondral ossification, whic...

Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects

Xian, C.
Cool, J.
Scherer, M.
Pyragius, C.
Fan, C.
Covino, M.
Foster, B.

January 2007

Methotrexate chemotherapy promotes osteoclast formation in the long bone of rats via increased pro-inflammatory cytokines and enhanced NF-kappa B activation

King, T.
Georgiou, K.
Cool, J.
Scherer, M.
Ang, E.
Foster, B.
Xu, J.
Xian, C.

January 2012

Cancer chemotherapy with methotrexate (MTX) is known to cause bone loss. However, the underlying mec...

Effects of methotrexate on human bone cell respones to mechanical stimulation.

Elliot, K. J
Millward-Sadler, S. J
Wright, M. O
Robb, J E
Wallace, W. H. B
Salter, D M

October 2004

Objectives. Methotrexate (MTX), which is prescribed in the treatment of malignancy and autoimmune di...

The role of osteocyte apoptosis in cancer chemotherapy-induced bone loss

Shandala, T.
Ng, Y.
Hopwood, B.
Yip, Y.
Foster, B.
Xian, C.

January 2012

Intensive cancer chemotherapy leads to significant bone loss, the underlying mechanism of which rema...

Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow

Georgiou, K.
Scherer, M.
Fan, C.
Cool, J.
King, T.
Foster, B.
Xian, C.

January 2012

Intensive use of cancer chemotherapy is increasingly linked with long-term skeletal side effects suc...

Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis

Ji Yeon Sung
Jang Hee Hong
Hyung Sik Kang
In Pyo Choi
Sang Deok Lim
June Kyu Lee
Jeong Ho Seok
Jae Heun Lee
Gang Min Hur

January 2000

Various cytokines and reactive oxygen species (ROS) play a fundamental role in the inflammatory and ...

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro

Annussek Tobias
Kleinheinz Johannes
Thomas Szuwart
Joos Ulrich
Wermker Kai

September 2012

Abstract Introduction Due to increasing use of disease modifying antirheumatic drugs (DMARDs) as fir...

Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast´s proliferation in vitro

Annussek, T. (Tobias)
Kleinheinz, J. (Johannes)
Szuwart, T. (Thomas)
Joos, U. (Ulrich)
Wermker, K. (Kai)

March 2013

Introduction: Due to increasing use of disease modifying antirheumatic drugs (DMARDs) as first line ...

The short- and long-term effects of methotrexate on the rat skeleton

Wheeler, D L
Vander Griend, R A
Wronski, T J
Miller, G J
Keith, E E
Graves, James, PhD

February 1995

Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has ...

Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis.

Gerards, A.H.
Lathouder, S de
Groot, E.R.
Dijkmans, B.A.C.
Aarden, L.A.

January 2003

OBJECTIVES: To analyse whether the beneficial effects of methotrexate in rheumatoid arthritis (RA) c...

Effects of Resveratrol Supplementation on Methotrexate Chemotherapy‐Induced Bone Loss

Alice Lee

March 2017

Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...

Effects of resveratrol supplementation on methotrexate chemotherapy-induced bone loss

Lee, Alice M. C.
Shandala, Tetyana
Soo, Pei Pei
Su, Yu-Wen
King, Tristan J.
Chen, Ke-Ming
Howe, Peter R.
Xian, Cory J.

January 2017

Intensive cancer chemotherapy is known to cause bone defects, which currently lack treatments. This ...

A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis

Le Goff, Benoit
Soltner, Elise
Charrier, Céline
Maugars, Yves
Rédini, Françoise
Heymann, Dominique
Berthelot, Jean-Marie

January 2009

International audienceIntroductionOsteoclasts play a key role in the pathogenesis of bone erosion an...

Mechanism of Action of Methotrexate: Experimental Evidence that Methotrexate Blocks the Binding of Interleukin 1 β to the Interleukin 1 Receptor on Target Cells

Marlene Brody
Ingrid B Hm
R. Bauer

January 1993

Summary: Interleukin 1, a multifunctional cytokine, plays a central role in inflammatory processes a...

Prevention of methotrexate chemotherapy-induced bone growth arrest and osteoporosis with folinic acid.

Fan, Chiaming

January 2011

During childhood and adolescence, bone continues to lengthen through endochondral ossification, whic...

Direct effects of methotrexate on osteoblasts 1) Methotrexate Suppresses Inflammatory Agonist Induced Interleukin 6 Synthesis in Osteoblasts 2) Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts

Abstract

Extracted data

Direct effects of methotrexate on osteoblasts 1) Methotrexate Suppresses Inflammatory Agonist Induced Interleukin 6 Synthesis in Osteoblasts 2) Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts

Abstract

Extracted data

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