Abstract We study constraints on the effective field theory (EFT) from the relative entropy between two theories: we refer to these as target and reference theories. The consequence of the non-negativity of the relative entropy is investigated by choosing some reference theories for a given target theory. We consider the target and reference theories described by field theories, quantum mechanical models, etc. It is found that the constraints on EFTs, e.g., the single massless scalar field with the dimension-eight operator, and SMEFT dimension-eight bosonic operators, arise when the higher-derivative operators are generated by the interaction between heavy and light fields. In particular, the constraints on the SMEFT dimension-eight bosonic...