Abstract Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies. Therefore, the key factor for cell viability, expansion, modification, and functionality is the optimal combination of medium and T cell activator as well as their regulatory compliance for later manufacturing under Good Manufacturing Practice (GMP). In this study, we compared two protocols for CAR-mRNA-modified T cell generation using our current lab-scale process, analyzed all mentioned parameters, and evaluated the protocols’ potential for upscaling and process development of mRNA-based CAR-T cell therapies
Autologous chimeric antigen receptor T-cells (CAR T-cells) have been proposed as a possible treatmen...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...
Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T-cells (CA...
Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T-cells (CA...
Adoptive cancer immunotherapy using chimeric antigen receptor (CAR) engineered T-cells holds great p...
Manufacturing process is an important and complex factor for preparing chimeric antigen receptor (CA...
Chimeric Antigen Receptor T (CAR-T) cells are certainly an important therapy for patients with relap...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates ...
Redirected T cells genetically modified with a chimeric antigen receptor (CAR) have induced spectacu...
Development of semi-automated devices that can reduce the hands-on time and standardize the producti...
Autologous chimeric antigen receptor T-cells (CAR T-cells) have been proposed as a possible treatmen...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...
Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T-cells (CA...
Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T-cells (CA...
Adoptive cancer immunotherapy using chimeric antigen receptor (CAR) engineered T-cells holds great p...
Manufacturing process is an important and complex factor for preparing chimeric antigen receptor (CA...
Chimeric Antigen Receptor T (CAR-T) cells are certainly an important therapy for patients with relap...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Chimeric antigen receptor T‐cell (CAR‐T) therapies have proven clinical efficacy for the treatment o...
Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates ...
Redirected T cells genetically modified with a chimeric antigen receptor (CAR) have induced spectacu...
Development of semi-automated devices that can reduce the hands-on time and standardize the producti...
Autologous chimeric antigen receptor T-cells (CAR T-cells) have been proposed as a possible treatmen...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing inte...