BACKGROUND: Massive online open cources (MOOCs) are a new chapter in the topic of teaching–learning in higher education, which have been able to acquire a significant and valuable position in higher education and prestigious universities worldwide in line with the advancement of technology. The present study was conducted pursuing the goal to investigating the effect of use of MOOCs in the development of virtual education in universities of medical sciences in the first macro-region of countrywide territorial planning.MATERIALS AND METHODS: This research is based on a mixed method and practical in terms of purpose, and it was carried out in 2021 and 2022 in first macro-region of countrywide regional planning Medical Sciences Universities. T...