Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in cancer. In recent years, PPIs have emerged as promising targets for rational drug design, primarily because their high specificity facilitates targeting of disease-related signaling pathways. However, obstacles exist at the molecular level that arise from the properties of the interaction interfaces and the propensity of small molecule drugs to interact with more than one cleft surface. The difficulty in identifying small molecules that act as activators or inhibitors to counteract the biolog...
Protein-protein interactions (PPIs) are ubiquitous in essential biological processes such as cell pr...
Protein-protein interactions (PPIs) are vital to many biological processes, including gene expressio...
Protein–protein interactions (PPIs) are central to most biological processes, and represent novel ta...
Protein-protein interactions (PPIs) underlie most biological processes. An increasing interest to in...
Small-molecule inhibition of the direct protein–protein interactions that mediate many important bio...
Protein-protein interactions (PPIs) underlie the majority of biological processes, signaling, and di...
Physical interactions among proteins constitute the backbone of cellular function, making them an at...
We describe a computational protocol to aid the design of small molecule and peptide drugs that targ...
Protein-protein interactions (PPIs) are key drug targets and recent breakthroughs in this area are p...
International audienceProtein-protein interactions (PPI) are involved in vital cellular processes an...
The past 20 years have seen many advances in our understanding of protein-protein interactions (PPIs...
An understanding of the underlying mechanisms by which proteins engage and communicate within the co...
Protein–protein interactions (PPIs) form the molecular basis for almost every phenomenon of life inc...
Treating protein-protein interactions as a novel and highly promising class of drug targets, this vo...
Modulating protein interaction pathways may lead to the cure of many diseases. Known protein–protein...
Protein-protein interactions (PPIs) are ubiquitous in essential biological processes such as cell pr...
Protein-protein interactions (PPIs) are vital to many biological processes, including gene expressio...
Protein–protein interactions (PPIs) are central to most biological processes, and represent novel ta...
Protein-protein interactions (PPIs) underlie most biological processes. An increasing interest to in...
Small-molecule inhibition of the direct protein–protein interactions that mediate many important bio...
Protein-protein interactions (PPIs) underlie the majority of biological processes, signaling, and di...
Physical interactions among proteins constitute the backbone of cellular function, making them an at...
We describe a computational protocol to aid the design of small molecule and peptide drugs that targ...
Protein-protein interactions (PPIs) are key drug targets and recent breakthroughs in this area are p...
International audienceProtein-protein interactions (PPI) are involved in vital cellular processes an...
The past 20 years have seen many advances in our understanding of protein-protein interactions (PPIs...
An understanding of the underlying mechanisms by which proteins engage and communicate within the co...
Protein–protein interactions (PPIs) form the molecular basis for almost every phenomenon of life inc...
Treating protein-protein interactions as a novel and highly promising class of drug targets, this vo...
Modulating protein interaction pathways may lead to the cure of many diseases. Known protein–protein...
Protein-protein interactions (PPIs) are ubiquitous in essential biological processes such as cell pr...
Protein-protein interactions (PPIs) are vital to many biological processes, including gene expressio...
Protein–protein interactions (PPIs) are central to most biological processes, and represent novel ta...