Dasatinib and ponatinib induce expression of the P-selectin glycoprotein ligand-1 on leukocytes.

A. Representative western blot of U937 cells treated for 24 hours with the indicated TKIs. B. Quantification of PSGL1 relative to GAPDH loading control for cells treated with indicated TKI versus DMSO control. Data presented as mean ± SEM, with N = 4 independent experiments per treatment. Statistical analysis by one way ANOVA with Dunnett’s multiple comparisons test with comparison of each mean to DMSO. ** p < 0.01.