Effect of different time intervals between individual doses on tumor growth.

Simulation of different experimental protocols consisting of spacing each single dose by a given number of days, from 7 to 98. This patient received 80 doses of TMZ according to the classic cyclic protocol (black line). The longer the interval between doses, the longer the time to reach fatal volume (OS). However, tumor control is lost from 42 days between each dose. Error bars represent 18% of error. Inferior horizontal line shows minimum attained volume.