Dermatologic pathology in MAYV-infected rhesus macaques.

At 10 dpi with MAYV, macaque skin sections were collected during necropsy, fixed, paraffin embedded, sectioned and stained for examination with hematoxylin and eosin (HE). (B; Bar = 1 cm) A maculopapular rash extends from the ventral abdomen to the flanks and inguinal region of NHP 3. (A; Bar = 100 μm. C; Bar = 50 μm) Sections of a maculopapular rash in the abdominal skin displaying multifocal acanthosis, mild dyskeratosis, superficial dermal edema, and perivascular lymphocytic inflammation in the superficial dermis. (D; Bar = 100 μm) The thoracic skin had similar perivascular and perifollicular lymphocytic aggregates. (E; Bar = 100 μm) Thoracic skin from NHP 1 with mild perivascular lymphocytic inflammation in the superficial dermis. (F; Bar = 100 μm) Normal thoracic skin from NHP 2.