The performance of DePTH models trained on Emerson data.

(A) the ROC curve of DePTH prediction on test data (part of Emerson data) for HLA-I and HLA-II, respectively. (B) Violin plots for the TCR-HLA association scores predicted by DePTH on three sets of TCR-HLA pairs: the positive pairs of Emerson test data, the negative pairs of Emerson test data, and the 54 external positive TCR-HLA pairs from solved TCR-pMHC-I structures provided by Szeto et al. [15]. The scores are given by DePTH model trained on Emerson training data. (C) and (D) compare the performance of DePTH and CLAIRE on McPAS test data while both models are trained on McPAS data. (C) ROC curves of prediction scores across all HLA-I alleles. (D) Comparison of allele-wise AUCs.