The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional biological roles for VWF, and in particular suggest that VWF may play an important role in regulating inflammatory responses. However, the molecular mechanisms through which VWF exerts its immuno-modulatory effects remain poorly understood. In this study, we report that VWF binding to macrophages triggers downstream MAP kinase signaling, NF-κB activation and production of pro-inflammatory cytokines and chemokines. In addition, VWF binding also drives macrophage M1 polarization and shifts macrophage metabolism towards glycol...
von Willebrand factor (VWF) is a large adhesive glycoprotein with established functions in hemostasi...
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the ini...
Von Willebrand factor (VWF) is a mechano-sensitive protein with crucial functions in normal hemostas...
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemo...
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary haem...
Von Willebrand factor (VWF) is a plasma protein that circulates as an array of multimerized subunits...
Abstract von Willebrand factor (vWF) is a multimeric glycoprotein essential for hemostasis after vas...
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular infla...
Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand diseas...
THESIS 9024Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet te...
Von Willebrand factor (VWF), a key player in hemostasis, is increasingly recognized as a proinflamma...
Von Willebrand Factor (vWF) is a well-known mediator of platelet adhesion to the vessel wall and of ...
International audienceObjective—von Willebrand factor (VWF) is crucial to hemostasis, but also plays...
Von Willebrand disease (VWD) type 2B is characterized by mutations causing enhanced binding of von W...
muscle cell proliferation and tumor cells metastasis. In-terestingly, vWF has also been implicated i...
von Willebrand factor (VWF) is a large adhesive glycoprotein with established functions in hemostasi...
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the ini...
Von Willebrand factor (VWF) is a mechano-sensitive protein with crucial functions in normal hemostas...
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemo...
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary haem...
Von Willebrand factor (VWF) is a plasma protein that circulates as an array of multimerized subunits...
Abstract von Willebrand factor (vWF) is a multimeric glycoprotein essential for hemostasis after vas...
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of vascular infla...
Enhanced von Willebrand factor (VWF) clearance is important in the etiology of von Willebrand diseas...
THESIS 9024Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet te...
Von Willebrand factor (VWF), a key player in hemostasis, is increasingly recognized as a proinflamma...
Von Willebrand Factor (vWF) is a well-known mediator of platelet adhesion to the vessel wall and of ...
International audienceObjective—von Willebrand factor (VWF) is crucial to hemostasis, but also plays...
Von Willebrand disease (VWD) type 2B is characterized by mutations causing enhanced binding of von W...
muscle cell proliferation and tumor cells metastasis. In-terestingly, vWF has also been implicated i...
von Willebrand factor (VWF) is a large adhesive glycoprotein with established functions in hemostasi...
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the ini...
Von Willebrand factor (VWF) is a mechano-sensitive protein with crucial functions in normal hemostas...