miR-34a-5p affects the EZH2 protein pathway.
- Shengjuan Lu (17427545)
- Lin Zeng (161089)
- Guojun Mo (2244643)
- Danqing Lei (816215)
- Yuanhong Li (2414860)
- Guodi Ou (17427548)
- Hailian Wu (10688266)
- Jie Sun (74648)
- Chao Rong (2032945)
- Sha He (1514137)
- Dani Zhong (17427551)
- Qing Ke (577483)
- Qingmei Zhang (14200580)
- Xiaohong Tan (485470)
- Hong Cen (577481)
- Xiaoxun Xie (17427554)
- Chengcheng Liao (12402943)
Publication date
November 2023
DOIAbstract
(A) Binding sites of EZH2 and miR-34a-5p were predicted through bioinformatics analysis. (BⅠ-Ⅱ) Double luciferase reporter experiment confirmed this prediction. (CⅠ-Ⅱ) Expression of EZH2 was increased in lymphoma cells and negatively correlated with miR-34a-5p. (DⅠ-Ⅱ) Overexpression of miR-34a-5p resulted in significant inhibition of the EZH2 signaling pathway. (E, F) miR-34a-5p inhibitor significantly reversed the EZH2 protein inhibition caused by SNHG17 knockdown. *P < 0.05, **P < 0.01, ***P < 0.001.</p
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