Simulated drug exposures after administration of WHO recommended doses and weight bands.

Simulated rifampicin, isoniazid, and pyrazinamide area under the curve from time zero to 24 h (AUC0-24) after dose and maximum concentrations (Cmax) at steady state, versus body weight, with concentrations achieved after administration of the WHO-recommended doses and weight-bands with the existing FDC formulation. The maroon boxes represent patients max and AUC0-24. The box indicates the interquartile range, while the whiskers denote the 2.5th and the 97.5th percentiles. Figure A in S1 Text shows WHO-recommended doses and weight-bands with weight stratified per kilogram. FDC, fixed-dose combination; WHO, World Health Organization.