Layered Fibrous Scaffolds/Membranes in Wound Healing

Skin is the largest organ of the human body acting as a barrier to protect the body from external effects and trauma. As a result of external physical damages or physiological disorders such as diabetes, skin tissue is disrupted, and cellular integrity is lost in the wounded site. Design and production of functional bioactive wound dressing matrices to protect the injured area, assist the wound healing process and guide the regeneration of healthy tissue are of utmost importance. Considering the complexity of the wound healing process and challenging requirements to fulfill the clinical need in terms of both healing and regeneration, multi-layered fibrous membranes/scaffolds offer an effective strategy for the design and development of multi-functional wound-healing matrices. Such matrices act to stimulate the wound-healing cascade by combining different materials with different physicochemical and structural properties in each layer and integration of various bioactive molecules and therapeutic agents