The aim of this paper is to look at the joint impact of culture and institutions on economic development by operationalizing the cultural and institutional multipliers conceptualized in the literature. The study uses regression analyses to estimate the two multipliers which are key in an understanding of the interaction of culture and institutions. As for culture, two layers are distinguished, deep culture (values) and a slow-moving cultural layer (beliefs). The cross-country empirical analyses, including IV estimations, provide evidence that the two cultural layers "behave" differently. Deep culture is not a substitute for (better) institutions, however, high-quality institutions can substitute improvement in deep culture, while in the maj...