Gastrointestinal (GI) symptoms are highly prevalent among individuals with autism spectrum disorder (ASD), but the molecular link between ASD and GI dysfunction remains poorly understood. The enteric nervous system (ENS) is critical for normal GI motility and has been shown to be altered in mouse models of ASD and other neurological disorders. Contactin-associated protein-like 2 (Cntnap2) is an ASD-related synaptic cell-adhesion molecule important for sensory processing. In this study, we examine the role of Cntnap2 in GI motility by characterizing Cntnap2’s expression in the ENS and assessing GI function in Cntnap2 mutant mice. We find Cntnap2 expression predominately in enteric sensory neurons. We further assess in vivo and ex vivo GI mot...
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with core symptoms of ...
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficit...
SummaryNeurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core b...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
© 2020 Madusani Herath Maduwelthanne Herath MudiyanselageAutism patients are four times more likely ...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in soci...
SummaryAlthough many genes predisposing to autism spectrum disorders (ASD) have been identified, the...
The establishment and maintenance of neuronal circuits depends on tight regulation of syn-aptic cont...
International audienceAutism Spectrum Disorders (ASDs) are neurodevelopmental disorders defined by i...
Autism spectrum disorder (ASD) is characterized by social interaction and communication impairments,...
<p>Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification o...
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficit...
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with core symptoms of ...
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficit...
SummaryNeurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core b...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
© 2020 Madusani Herath Maduwelthanne Herath MudiyanselageAutism patients are four times more likely ...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via...
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Mul...
Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in soci...
SummaryAlthough many genes predisposing to autism spectrum disorders (ASD) have been identified, the...
The establishment and maintenance of neuronal circuits depends on tight regulation of syn-aptic cont...
International audienceAutism Spectrum Disorders (ASDs) are neurodevelopmental disorders defined by i...
Autism spectrum disorder (ASD) is characterized by social interaction and communication impairments,...
<p>Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification o...
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficit...
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder with core symptoms of ...
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficit...
SummaryNeurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core b...