Supplementary Table 2 contains the statistical analysis for pSer2 downregulation in SU-DHL-4 and SU-DHL-10 cell lines across CDK9 inhibitor treatments.</p
Enitociclib treatment confers a robust shift in transcriptional activity in MYC+ DLBCL cell lines. A...
Deregulation of the cyclin-dependent kinases (CDKs) has been implicated in the pathogenesis of multi...
© 2016 Dr. Gareth Peter GregoryAggressive B-cell lymphomas include diffuse large B-cell lymphoma, Bu...
Supplementary Table 3 contains the top DEGS from an unbiased analysis of RNAseq from MYC+ DLBCL cell...
Supplementary Table 1 shows the enitociclib toxicity in a panel of lymphoma cell lines ranked by IC5...
Supplementary Table 5 shows estimated pharmacodynamic parameters for MYC and MCL1 mRNA in blood foll...
Supplementary Table 6 captures the maximal downregulation timepoint for novel and known DEGs post en...
Response and pharmacokinetics properties of patients with DH-DLBCL and other patients with MYC+ NHL ...
Supplementary Figure 1 shows the principal component analysis of RNA sequencing of either SU-DHL-4 a...
Supplementary Figure 2: Downregulation of MYC and MCL1 is detected in the whole blood of Enitociclib...
Supplementary Table 4 shows the baseline characteristics of DH-DLBCL and other MYC+ NHL Patients (n=...
Enitociclib delivers robust inhibition of RNA polymerase II Ser2 phosphorylation for up to 48 hours ...
Enitociclib depletes mRNA transcripts, MYC and MCL1; downregulates Myc and Mcl-1 protein levels and ...
Comparison of DEGs identified in MYC+ DLBCL cell lines to blood samples from enitociclib-treated pat...
Enitociclib treatment results in complete regression of MYC-overexpressing SU-DHL-10 lymphoma growth...
Enitociclib treatment confers a robust shift in transcriptional activity in MYC+ DLBCL cell lines. A...
Deregulation of the cyclin-dependent kinases (CDKs) has been implicated in the pathogenesis of multi...
© 2016 Dr. Gareth Peter GregoryAggressive B-cell lymphomas include diffuse large B-cell lymphoma, Bu...
Supplementary Table 3 contains the top DEGS from an unbiased analysis of RNAseq from MYC+ DLBCL cell...
Supplementary Table 1 shows the enitociclib toxicity in a panel of lymphoma cell lines ranked by IC5...
Supplementary Table 5 shows estimated pharmacodynamic parameters for MYC and MCL1 mRNA in blood foll...
Supplementary Table 6 captures the maximal downregulation timepoint for novel and known DEGs post en...
Response and pharmacokinetics properties of patients with DH-DLBCL and other patients with MYC+ NHL ...
Supplementary Figure 1 shows the principal component analysis of RNA sequencing of either SU-DHL-4 a...
Supplementary Figure 2: Downregulation of MYC and MCL1 is detected in the whole blood of Enitociclib...
Supplementary Table 4 shows the baseline characteristics of DH-DLBCL and other MYC+ NHL Patients (n=...
Enitociclib delivers robust inhibition of RNA polymerase II Ser2 phosphorylation for up to 48 hours ...
Enitociclib depletes mRNA transcripts, MYC and MCL1; downregulates Myc and Mcl-1 protein levels and ...
Comparison of DEGs identified in MYC+ DLBCL cell lines to blood samples from enitociclib-treated pat...
Enitociclib treatment results in complete regression of MYC-overexpressing SU-DHL-10 lymphoma growth...
Enitociclib treatment confers a robust shift in transcriptional activity in MYC+ DLBCL cell lines. A...
Deregulation of the cyclin-dependent kinases (CDKs) has been implicated in the pathogenesis of multi...
© 2016 Dr. Gareth Peter GregoryAggressive B-cell lymphomas include diffuse large B-cell lymphoma, Bu...