Gemcitabine, BEZ235, GDC-0941, TP-3654, and AUM302 inhibit viability of multiple pancreatic cancer cell lines.

Pancreatic cancer cell lines BxPC-3 (A), Capan-2 (B), MIA PaCa-2 (C), PANC-1 (D), and Hs766T (E) were treated with variable concentrations of gemcitabine or BEZ235 or GDC-0941 or TP-3654 or AUM302 twenty-four hours after seeding. Cells were treated with test compounds for 72 hours and cell viability was measured using Cell Titer-Glo. Each experiment was performed in triplicate and the results are shown as mean ±SD (N = 3).