Tumor sphere/organoid-forming cells in p53/BRCA1-deficient mouse mammary tumors are largely FZD7<sup>+</sup>.
- Aina He (357529)
- Songhai Tian (6013694)
- Oded Kopper (17364730)
- Daniel J. Horan (17364733)
- Peng Chen (6514)
- Roderick T. Bronson (7386482)
- Ren Sheng (7959113)
- Hao Wu (65943)
- Lufei Sui (17364736)
- Kun Zhou (347672)
- Liang Tao (248968)
- Quan Wu (444646)
- Yujing Huang (519658)
- Zan Shen (280887)
- Sen Han (2437435)
- Xueqing Chen (499722)
- Hong Chen (108084)
- Xi He (208289)
- Alexander G. Robling (8905064)
- Rongsheng Jin (378622)
- Hans Clevers (211819)
- Dongxi Xiang (3693031)
- Zhe Li (219258)
- Min Dong (123378)
Publication date
November 2023
DOIAbstract
(A) FACS analysis using FITC-TcdBFBD and anti-FZD7 antibody showed that primary p53/BRCA1-deficient tumors cells targeted by TcdBFBD are largely FZD7+. (B) Representative images showing the tumorspheres formed from p53/BRCA1-deficient tumor cells. (C) Tumorsphere cells cultured from p53/BRCA1-deficient tumors were examined by FACS analysis using an anti-FZD7 antibody. (D) Representative images showing the tumor organoid formed from p53/BRCA1-deficient tumor cells. (E) FACS analysis of FZD7+ cells in the tumor organoids described in (D) showing that most organoid cells express FZD7. Numerical values are in S1 Data. (PDF)</p
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