Genetic predictors belong to a handful of metabolic subsystems.

A: Manhattan-like plot showing the effect sizes (y-axis) of genes grouped by yeast metabolic subsystems (x-axis; arbitrary colors). We find that genes with large effect sizes belong to a handful of subsystems related to protein synthesis, cell membrane and organelle compartmentalization. B: Effect sizes of all predictors identified in the PGS (colors as in Fig 2) and their corresponding metabolic subsystem. (TIF)