MDIC3

The crosstalk among cells is vital to maintain the biological function and the intactness of systems. Most of the existing methods for the inference of cell-cell communication are based on ligand-receptor (L-R) expression, and they focus on the study between two cells. Thus, the final communication inference results are particularly sensitive to the completeness and accuracy of the prior biological knowledge. Whereas existing L-R researches mainly focus on humans, most of the existing methods can only infer cell-cell communication for human. As far as we know, there is no effective method to avoid species limitation, currently. Here, we proposed the MDIC3, an unsupervised tool to infer cell-cell communication in any species, and the results will not be limited by specific L-R pairs or signaling pathways. By comparing with the existing methods for the inference of cell-cell communication, the MDIC3 obtained better performance in both humans and mice.