The incidence of melanoma, the most fatal dermatological cancer, has dramatically increased over the last few decades. Modern targeted therapy with kinase inhibitors induces potent clinical responses, but drug resistance quickly develops. Combination therapy improves treatment outcomes. Therefore, novel inhibitors targeting aberrant proliferative signaling in melanoma via the MAPK/ERK and PI3K/AKT pathways are urgently needed. Biosensors were combined that report on ERK/AKT activity with image-based highcontent screening and HPLC-based activity profiling. An in-house library of 2576 plant extracts was screened on two melanoma cell lines with different oncogenic mutations leading to pathological ERK/AKT activity. Out of 140 plant extract hit...
Melanoma is among the most heterogeneous and aggressive type of cancers. The BRAFV600E mutation, fou...
Melanomas are disease entities driven in part by the mitogen activated protein kinase (MAPK) pathway...
The RAS–RAF–MEK–ERK and PI3K–AKT–mTOR signaling pathways are activated through multiple mechanisms a...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The incidence of melanoma, the most fatal dermatological cancer, has dramatically increased over the...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The scaffold diversity of natural products has given rise to the development of many drugs. Around o...
The PI3K/AKT and MAPK/ERK pathways are frequently mutated in metastatic melanoma. In a screen of ove...
In melanoma, the PI3K-AKT-mTOR (AKT) and RAF-MEK-ERK (MAPK) signaling pathways are constitutively ac...
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have...
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have...
Despite the broad prevention programs and early detection and therapy progress, melanoma of skin is ...
Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to curre...
Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to cur...
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease....
Melanoma is among the most heterogeneous and aggressive type of cancers. The BRAFV600E mutation, fou...
Melanomas are disease entities driven in part by the mitogen activated protein kinase (MAPK) pathway...
The RAS–RAF–MEK–ERK and PI3K–AKT–mTOR signaling pathways are activated through multiple mechanisms a...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The incidence of melanoma, the most fatal dermatological cancer, has dramatically increased over the...
Melanoma is the deadliest form of skin cancer with a dramatically increasing incidence rate over the...
The scaffold diversity of natural products has given rise to the development of many drugs. Around o...
The PI3K/AKT and MAPK/ERK pathways are frequently mutated in metastatic melanoma. In a screen of ove...
In melanoma, the PI3K-AKT-mTOR (AKT) and RAF-MEK-ERK (MAPK) signaling pathways are constitutively ac...
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have...
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have...
Despite the broad prevention programs and early detection and therapy progress, melanoma of skin is ...
Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to curre...
Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to cur...
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease....
Melanoma is among the most heterogeneous and aggressive type of cancers. The BRAFV600E mutation, fou...
Melanomas are disease entities driven in part by the mitogen activated protein kinase (MAPK) pathway...
The RAS–RAF–MEK–ERK and PI3K–AKT–mTOR signaling pathways are activated through multiple mechanisms a...