Toxoplasma gondii is a highly prevalent protozoan that infects a broad spectrum of warm-blooded animals. Profilin is a critical protein that plays a role in the movement and invasion of T. gondii. In the current study, we assessed how profilin stimulates inflammasomes and how it induces transcription and secretion of IL-1β. For this purpose, we assessed the level of TLR 2, 4, 5, and 9 expressions in a THP-1 cell line treated with profilin from T. gondii (TgP). In addition, we analyzed the expression levels of various inflammasomes, as well as IL-1β, and IL-18 in THP-1 cells treated with the NLRP3 inhibitor MCC950. TgP significantly increased the expression of TLR5 but the expression of TLR2, 4, and 9 was not significantly increased. In addi...
Neutrophils are a major player in host immunity to infection; however, the mechanisms by which human...
Toxoplasma gondii (T. gondii) is the protozoan parasite that causes toxoplasmosis, a potentially fat...
Up to a third of the world's population is infected with <i>Toxoplasma gondii.</i> Natural infection...
Apicomplexan parasites exhibit actin–dependent gliding motility that is essential for migration acro...
SummaryApicomplexan parasites exhibit actin-dependent gliding motility that is essential for migrati...
Ly6C+ inflammatory monocytes are essential to host defense against Toxoplasma gondii, Listeria monoc...
Abstract Background Toxoplasma gondii can invade and replicate in all nucleated cells in a wide rang...
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens b...
Toxoplasma gondii is a common opportunistic protozoan pathogen that can parasitize the karyocytes of...
UNLABELLED: Induction of immunity that limits Toxoplasma gondii infection in mice is critically depe...
Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the...
ABSTRACT Induction of immunity that limits Toxoplasma gondii infection in mice is critically depende...
ABSTRACT Interleukin-1β (IL-1β) functions as a key regulator of inflammation and innate immunity. ...
ABSTRACT Interleukin-1 (IL-1) functions as a key regulator of inflammation and innate immunity. The...
Toxoplasma gondii is an obligate intracellular eukaryotic parasite that is estimated to infect one-t...
Neutrophils are a major player in host immunity to infection; however, the mechanisms by which human...
Toxoplasma gondii (T. gondii) is the protozoan parasite that causes toxoplasmosis, a potentially fat...
Up to a third of the world's population is infected with <i>Toxoplasma gondii.</i> Natural infection...
Apicomplexan parasites exhibit actin–dependent gliding motility that is essential for migration acro...
SummaryApicomplexan parasites exhibit actin-dependent gliding motility that is essential for migrati...
Ly6C+ inflammatory monocytes are essential to host defense against Toxoplasma gondii, Listeria monoc...
Abstract Background Toxoplasma gondii can invade and replicate in all nucleated cells in a wide rang...
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens b...
Toxoplasma gondii is a common opportunistic protozoan pathogen that can parasitize the karyocytes of...
UNLABELLED: Induction of immunity that limits Toxoplasma gondii infection in mice is critically depe...
Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the...
ABSTRACT Induction of immunity that limits Toxoplasma gondii infection in mice is critically depende...
ABSTRACT Interleukin-1β (IL-1β) functions as a key regulator of inflammation and innate immunity. ...
ABSTRACT Interleukin-1 (IL-1) functions as a key regulator of inflammation and innate immunity. The...
Toxoplasma gondii is an obligate intracellular eukaryotic parasite that is estimated to infect one-t...
Neutrophils are a major player in host immunity to infection; however, the mechanisms by which human...
Toxoplasma gondii (T. gondii) is the protozoan parasite that causes toxoplasmosis, a potentially fat...
Up to a third of the world's population is infected with <i>Toxoplasma gondii.</i> Natural infection...