The scope of acid-mediated cyclative additions of electrophiles to tryptophan-derived α-amino nitriles for the synthesis of 10b-substituted-1,2,4,5,10b,10c-hexahydropyrrolo[1′,2′,3′:1,9a,9]imidazo[1,2-a]indoles analogues of indole alkaloids has been studied. The results demonstrate the high potential of the methodology for the synthesis of 10b-bromo-derivatives, by bromination with NBS, 10b-allyl-derivatives, by bromo-allyl exchange, and 10b-prenyl-derivatives, by reaction with prenyl bromide in the presence of Mg(NO3)2·6H20. Some of the new pyrroloimidazoindole derivatives displayed moderate μM cytotoxicities in human cancer cell lines and at 10 μg/mL inhibited more than 50% EGFR or HIF-1α.This work was supported by CICYT (SAF2006-01205). ...
Hydroxylated seco-analogs of cytotoxic phenanthroindolizidine alkaloids were prepared in good yields...
The indole scaffold has been recognized, over the years, as a model for the synthesis of compounds w...
A series of novel imidazopyridine derivatives of indole has been synthesized. All the synthesized d...
The scope of acid-mediated cyclative additions of electrophiles to tryptophan-derived α-amino nitril...
New indole alkaloid analogues, containing a 10b-methyl- or a 10b-hydroxy-1,2,4,5,10b,10c-hexahydropy...
Readily available proline derivatives can be transformed in just two steps into analogues of cytotox...
Heterocycles form a largest class of organic molecules which are of immense importance biologically ...
The current approach described the synthesis of a new series of indolylpyrrole derivatives through m...
AbstractIn view of known antitumor and cytotoxic properties of 2- and 3-pyridinyl substituted indole...
The tricyclic indole and tetracyclic quinoline heterocyclic systems were chosen from Naresh Kumar (N...
This thesis describes work carried out on the design of new routes to a range of bisindolylmaleimide...
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrro...
Heterocyclic rings are recognized as key components of many natural, semi-synthetic and synthetic mo...
A small library of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones has been synthesized and scr...
none9The synthesis and antitumor activity of a new series of E-3-(2-chloro-3-indolylmethylene)1,3-di...
Hydroxylated seco-analogs of cytotoxic phenanthroindolizidine alkaloids were prepared in good yields...
The indole scaffold has been recognized, over the years, as a model for the synthesis of compounds w...
A series of novel imidazopyridine derivatives of indole has been synthesized. All the synthesized d...
The scope of acid-mediated cyclative additions of electrophiles to tryptophan-derived α-amino nitril...
New indole alkaloid analogues, containing a 10b-methyl- or a 10b-hydroxy-1,2,4,5,10b,10c-hexahydropy...
Readily available proline derivatives can be transformed in just two steps into analogues of cytotox...
Heterocycles form a largest class of organic molecules which are of immense importance biologically ...
The current approach described the synthesis of a new series of indolylpyrrole derivatives through m...
AbstractIn view of known antitumor and cytotoxic properties of 2- and 3-pyridinyl substituted indole...
The tricyclic indole and tetracyclic quinoline heterocyclic systems were chosen from Naresh Kumar (N...
This thesis describes work carried out on the design of new routes to a range of bisindolylmaleimide...
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrro...
Heterocyclic rings are recognized as key components of many natural, semi-synthetic and synthetic mo...
A small library of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones has been synthesized and scr...
none9The synthesis and antitumor activity of a new series of E-3-(2-chloro-3-indolylmethylene)1,3-di...
Hydroxylated seco-analogs of cytotoxic phenanthroindolizidine alkaloids were prepared in good yields...
The indole scaffold has been recognized, over the years, as a model for the synthesis of compounds w...
A series of novel imidazopyridine derivatives of indole has been synthesized. All the synthesized d...