Shining a light on metabolic vulnerabilities in non-small cell lung cancer.

Metabolic reprogramming is a hallmark of cancer which contributes to essentialprocesses required for cell survival, growth, and proliferation. Non-small cell lung cancer(NSCLC) is the most common type of lung cancer and its genomic classification has given riseto the design of therapies targeting tumors harboring specific gene alterations that causeaberrant signaling. Lung tumors are characterized with having high glucose and lactate use,and high heterogeneity in their metabolic pathways. Here we review how NSCLC cells withdistinct mutations reprogram their metabolic pathways and highlight the potential metabolicvulnerabilities that might lead to the development of novel therapeutic strategies.