Leveraging the differential response of genes to mechanical loading may allow for the identification of novel therapeutics and we have recently established placental growth factor (PGF) as a mechanically augmented gene which promotes angiogenesis at higher doses and osteogenesis at lower doses. Herein, we sought to execute a mechanobiology-informed approach to regenerative medicine by designing a functionalized scaffold for the dose-controlled delivery of PGF which we hypothesized would be capable of promoting regeneration of critically-sized bone defects. Alginate microparticles and collagen/hydroxyapatite scaffolds were shown to be effective PGF-delivery platforms, as demonstrated by their capacity to promote angiogenesis in vitro. A PGF ...
Microparticles have been utilized as delivery vehicles of soluble factors to modify cellular behavio...
Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to s...
Tissue engineering aims to generate or facilitate regrowth or healing of damaged tissues by applying...
Although bone has an intrinsic capacity for self repair, the healing of large bone defects that typi...
The healing of large, critically sized bone defects remains an unmet clinical need in modern orthop...
This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a l...
This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a l...
In recent years, bone tissue engineering has emerged as a promising solution to the limitations of c...
A major limitation with current tissue-engineering approaches is creating functionally vascularized ...
This research introduces a delivery system for the release of an angiogenic and an osteogenic growth...
Bone regeneration consists of a series of complex biological events, that in vivo, requires the high...
Current therapies for delayed- or nonunion bone fractures are still largely ineffective. Previous st...
The clinical translation of bioactive scaffolds for the treatment of large segmental bone defects ha...
The capacity to deliver, temporally, bioactive growth factors in combination with appropriate progen...
The hypothesis of this study was that the extent of bone regeneration could be enhanced by using sca...
Microparticles have been utilized as delivery vehicles of soluble factors to modify cellular behavio...
Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to s...
Tissue engineering aims to generate or facilitate regrowth or healing of damaged tissues by applying...
Although bone has an intrinsic capacity for self repair, the healing of large bone defects that typi...
The healing of large, critically sized bone defects remains an unmet clinical need in modern orthop...
This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a l...
This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a l...
In recent years, bone tissue engineering has emerged as a promising solution to the limitations of c...
A major limitation with current tissue-engineering approaches is creating functionally vascularized ...
This research introduces a delivery system for the release of an angiogenic and an osteogenic growth...
Bone regeneration consists of a series of complex biological events, that in vivo, requires the high...
Current therapies for delayed- or nonunion bone fractures are still largely ineffective. Previous st...
The clinical translation of bioactive scaffolds for the treatment of large segmental bone defects ha...
The capacity to deliver, temporally, bioactive growth factors in combination with appropriate progen...
The hypothesis of this study was that the extent of bone regeneration could be enhanced by using sca...
Microparticles have been utilized as delivery vehicles of soluble factors to modify cellular behavio...
Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to s...
Tissue engineering aims to generate or facilitate regrowth or healing of damaged tissues by applying...