ABSTRACT: BACKGROUND: Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein/regenerating (PSP/reg) gene in surviving neighbour cells, and that PSP/reg1A protein is subsequently secreted from these cells. The objective of this study was to determine whether serum levels of PSP/reg1A are elevated during disease progression in HNF1A-MODY...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
ABSTRACT: BACKGROUND: Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A...
BACKGROUND: There is a significant clinical overlap between patients with hepatocyte nuclear factor ...
Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced β-cell mass, partially due to...
Objective: In diabetes, beta cell mass is not static but in a constant process of cell death and ren...
Context: There are interplays between the endocrine and exocrine pancreas.We recently reported an in...
Context: There are interplays between the endocrine and exocrine pancreas. Werecently reported an in...
In this project, we were interested in studying HNF1A-induced defects in the expression of genes inv...
Context: There are interplays between the endocrine and exocrine pancreas.We recently reported an in...
Type 2 diabetes is characterized by an inability to maintain normoglycemia due to impairments in bot...
Item does not contain fulltextAIMS/HYPOTHESIS: Histone deacetylases (HDACs) are promising pharmacolo...
Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 ...
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor expressed in ...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
ABSTRACT: BACKGROUND: Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A...
BACKGROUND: There is a significant clinical overlap between patients with hepatocyte nuclear factor ...
Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced β-cell mass, partially due to...
Objective: In diabetes, beta cell mass is not static but in a constant process of cell death and ren...
Context: There are interplays between the endocrine and exocrine pancreas.We recently reported an in...
Context: There are interplays between the endocrine and exocrine pancreas. Werecently reported an in...
In this project, we were interested in studying HNF1A-induced defects in the expression of genes inv...
Context: There are interplays between the endocrine and exocrine pancreas.We recently reported an in...
Type 2 diabetes is characterized by an inability to maintain normoglycemia due to impairments in bot...
Item does not contain fulltextAIMS/HYPOTHESIS: Histone deacetylases (HDACs) are promising pharmacolo...
Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 ...
Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor expressed in ...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...
Type 2 diabetes is characterized by insulin resistance and inadequate insulin secretion. In the adva...