Add to ORKGProtein kinase D2 (PKD2) is a serine/threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the rat kidney, PKD2 is specifically expressed in collecting duct principal cells predominantly at the apical membrane and with lower basal expression in cytosolic compartments. When rats were maintained on a Na+ depleted diet (<0.87 mmol Na+/kg) to increase plasma aldosterone levels, PKD2 became internalized to a cytoplasmic compartment. Treatment of murine M1 cortical collecting duct (M1-CCD) cells with aldosterone (10 nM) promoted PKD2 co-localization with the trans-Golgi network within 30 min. PKD2 underwent autophospho...
Fine tuning of Na + reabsorption takes place along the aldosterone-sensitive distal nephron (ASDN) ...
The renal aldosterone-sensitive distal tubule (ASDT) is crucial for sodium reabsorption and blood pr...
AbstractThe mechanisms by which aldosterone increases Na+, K+ ATPase and sodium channel activity in ...
Aldosterone is the key regulating hormone of whole body fluid and electrolyte balance. Perturbations...
Aldosterone treatment of M1-CCD cells stimulated an increase in epithelial Na+ channel (ENaC) alpha-...
Aldosterone is the key regulating hormone of whole-body fluid and electrolyte homeostasis. Perturbat...
Aldosterone plays a central role in Na+ homeostasis by controlling Na+ reabsorption in the aldostero...
The collecting duct of normal kidney exhibits significant activity of the MEK1/2-ERK1/2 pathway as s...
Aldosterone increases within 30 min renal Na+reabsorption and K+secretion by a mechanism that is tri...
The mineralocorticoid hormone aldosterone controls sodium reabsorption and BP largely by regulating ...
Prostaglandin E2 (PGE2) is the most abundant prostanoid in the kidney, affecting a wide range of ren...
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In...
This study was aimed at dissecting mechanisms of coordination between ENaC and Na,K-ATPase as well a...
Regulation of renal Na(+) transport is essential for controlling blood pressure, as well as Na(+) an...
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In...
Fine tuning of Na + reabsorption takes place along the aldosterone-sensitive distal nephron (ASDN) ...
The renal aldosterone-sensitive distal tubule (ASDT) is crucial for sodium reabsorption and blood pr...
AbstractThe mechanisms by which aldosterone increases Na+, K+ ATPase and sodium channel activity in ...
Aldosterone is the key regulating hormone of whole body fluid and electrolyte balance. Perturbations...
Aldosterone treatment of M1-CCD cells stimulated an increase in epithelial Na+ channel (ENaC) alpha-...
Aldosterone is the key regulating hormone of whole-body fluid and electrolyte homeostasis. Perturbat...
Aldosterone plays a central role in Na+ homeostasis by controlling Na+ reabsorption in the aldostero...
The collecting duct of normal kidney exhibits significant activity of the MEK1/2-ERK1/2 pathway as s...
Aldosterone increases within 30 min renal Na+reabsorption and K+secretion by a mechanism that is tri...
The mineralocorticoid hormone aldosterone controls sodium reabsorption and BP largely by regulating ...
Prostaglandin E2 (PGE2) is the most abundant prostanoid in the kidney, affecting a wide range of ren...
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In...
This study was aimed at dissecting mechanisms of coordination between ENaC and Na,K-ATPase as well a...
Regulation of renal Na(+) transport is essential for controlling blood pressure, as well as Na(+) an...
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In...
Fine tuning of Na + reabsorption takes place along the aldosterone-sensitive distal nephron (ASDN) ...
The renal aldosterone-sensitive distal tubule (ASDT) is crucial for sodium reabsorption and blood pr...
AbstractThe mechanisms by which aldosterone increases Na+, K+ ATPase and sodium channel activity in ...