Background: Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET degradation depends on the combined activity of two distinct DNases, DNase1 and DNase1-like 3 (DNase1L3) that preferentially digest double-stranded DNA (dsDNA) and chromatin, respectively. Methods: Here, we engineered a dual-active DNase with combined DNase1 and DNase1L3 activities and characterized the enzyme for its NET degrading potential in vitro. Furthermore, we produced a mouse model with transgenic expression of the dual-active DNase and analyzed body fluids of these animals for DNase1 a...
Cancer does not only affect surrounding tissues, but also leads to complications at distant sites. T...
Summary: Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of a...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiq...
Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and...
Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating b...
Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating b...
SummaryThe innate immune response plays a crucial role in satisfactory host resolution of bacterial ...
The innate immune response plays a crucial role in satisfactory host resolution of bacterial infecti...
peer reviewedNeutrophil extracellular traps (NETs) are networks of extracellular chromosomal DNA fib...
Soluble nucleases of the deoxyribonuclease 1 (DNase1) family facilitate DNA and chromatin disposal (...
Though only recently discovered, neutrophil extracellular traps (NETs) have rapidly attracted scient...
Immune checkpoint inhibitors can improve the prognosis of patients with advanced malignancy; however...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
<div><p>Neutrophil extracellular traps (NETs) comprise an ejected lattice of chromatin enmeshed with...
BACKGROUND Acute thrombotic microangiopathies (TMAs) are characterized by excessive microvascular...
Cancer does not only affect surrounding tissues, but also leads to complications at distant sites. T...
Summary: Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of a...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiq...
Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and...
Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating b...
Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating b...
SummaryThe innate immune response plays a crucial role in satisfactory host resolution of bacterial ...
The innate immune response plays a crucial role in satisfactory host resolution of bacterial infecti...
peer reviewedNeutrophil extracellular traps (NETs) are networks of extracellular chromosomal DNA fib...
Soluble nucleases of the deoxyribonuclease 1 (DNase1) family facilitate DNA and chromatin disposal (...
Though only recently discovered, neutrophil extracellular traps (NETs) have rapidly attracted scient...
Immune checkpoint inhibitors can improve the prognosis of patients with advanced malignancy; however...
The processes of secondary antibody diversification are initiated by the mutagenic, B cell specific ...
<div><p>Neutrophil extracellular traps (NETs) comprise an ejected lattice of chromatin enmeshed with...
BACKGROUND Acute thrombotic microangiopathies (TMAs) are characterized by excessive microvascular...
Cancer does not only affect surrounding tissues, but also leads to complications at distant sites. T...
Summary: Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of a...
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiq...